Egyptian Drug Authority Pyramids Branch | Egypt
Dr. Ehsan Khedre is a pharmaceutical biochemistry researcher whose work spans natural product pharmacology, nanotechnology, oxidative stress, and metabolic disease. After earning her B.Pharm (Ain-Shams University, Egypt, 2004), she completed an M.Sc. in Biochemistry (Zagazig University, 2011) and a Ph.D. (Al-Azhar University, 2018) on estrogenic effects of quercetin and its nanoparticles. She has held roles at Egypt’s National Organization for Drug Control & Research (NODCAR / EDA), advancing from drug control specialist to quality manager and researcher in biochemical laboratories. Her publication record (to date > 9 peer-reviewed articles) includes studies on hepatic fibrosis, nanocarrier enhancement of phytochemicals, metabolic syndrome models, and nanoparticle biodistribution. Her citation metrics h-index of 5, total documents 7, total citations 170 reflect her growing impact in pharmacology and toxicology. Her research interests include antioxidant and anti-inflammatory natural compounds, nanoparticle delivery systems, biochemical mechanisms of organ injury, and translational approaches to metabolic and hepatic diseases. She has also contributed by serving as reviewer for journals, receiving training in quality systems (ISO 9001 / ISO 17025), scientific writing, bioinformatics, and innovation, and participating in workshops on research skills. In sum, Dr. Khedre combines deep domain expertise, laboratory leadership, and interdisciplinary scholarship to advance discovery and application of therapeutics.
Featured Publications
Fayed, E. A., El-Sebaey, S. A., Ebrahim, M. A., Abu-Elfotuh, K., El-Sayed Mansour, R., Mohamed, E. K., Hamdan, A. M. E., Al-subaie, F. T., Albalawi, G. S., Albalawi, T. M., et al. (2025). Discovery of novel bicyclic and tricyclic cyclohepta[b]thiophene derivatives as multipotent AChE and BChE inhibitors, in-vivo and in-vitro assays, ADMET and molecular docking simulation. European Journal of Medicinal Chemistry, 117201.
Abu-Elfotuh, K., Kamel, G. A. M., Najm, M. A. A., Hamdan, A. M. E., Koullah, M. T., Fahmy, R. K. E., Aboelsoud, H. A., Alghusn, M. A., Albalawi, B. R., Atwa, A. M., et al. (2025). Modulating multiple molecular trajectories by nutraceuticals and/or physical activity in attention-deficit/hyperactivity disorder (ADHD)-like behaviors in rat pups. Journal of NeuroImmune Pharmacology.
Oudah, K. H., Najm, M. A. A., Ramsis, T. M., Ebrahim, M. A., Gohar, N. A., Abu-Elfotuh, K., Mohamed, E. K., Hamdan, A. M. E., Hamdan, A. M., Almotairi, R., et al. (2025). Unlocking therapeutic potential of novel thieno-oxazepine hybrids as multi-target inhibitors of AChE/BChE and evaluation against Alzheimer’s disease: In vivo, in vitro, histopathological, and docking studies. Pharmaceuticals, 18(8), 1214.
Nazeam, J. A., Black, I., Mulamoottil, V. A., Selim, N. M., El Shiekh, R. A., Abu-Elfotuh, K., Hamdan, A. M. E., Gowifel, A. M. H., Hafez, S. M., Mohamed, E. K., et al. (2025). Okra seed polysaccharides mitigate neuroinflammation and cognitive impairment via modulation of Nrf2/HO-1, HMGB1/RAGE/TLR4/NF-κB, NLRP3/Caspase-1, JAK-2/STAT-3, AMPK/SIRT1/m-TOR, PI3K/AKT/CREB/BDNF/TrkB and PERK/CHOP/Bcl-2 axes. International Immunopharmacology, 114110.
Mohamed, E. K., Fathy, M. M., Sadek, N. A., & Eldosoki, D. E. (2024). The effects of rutin coat on the biodistribution and toxicities of iron oxide nanoparticles in rats. Journal of Nanoparticle Research, 26(3), 49.