Francisco Sierra Lopez | Medicine and Health Sciences | Best Researcher Award

Dr. Francisco Sierra Lopez| Medicine and Health Sciences | Best Researcher Award

Guest researcher, High Specialty Regional Hospital of Ixtapaluca (HRAEI), Mexico

Francisco Sierra López is a guest researcher at the High Specialty Regional Hospital of Ixtapaluca (HRAEI), Mexico. A molecular biologist and biomedical innovator, he specializes in the study of extracellular vesicles and their role in infections, cancer, and immunological processes. He received his Bachelor’s in Biology and completed postdoctoral research at the National Autonomous University of Mexico (UNAM), followed by a Master’s and Ph.D. in Science from the Center for Research and Advanced Studies (CINVESTAV-IPN). His interdisciplinary approach led to the discovery and patenting of immunogenic giant extracellular vesicles (VEGs) derived from protozoan parasites. Francisco has authored four internationally recognized publications and is credited with both a national and a WIPO-registered patent. His research continues to explore novel diagnostic and therapeutic avenues in oncology and infectious diseases.

Profile

Google Scholar

Education

Francisco Sierra López holds a Bachelor of Science in Biology and pursued his postdoctoral training at the National Autonomous University of Mexico (UNAM), one of Latin America’s most prestigious research institutions. He earned his Master’s and Doctorate degrees in Science from the Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN), specializing in cell and molecular biology. During his academic tenure, he engaged in groundbreaking studies on protozoan parasites and molecular signaling, which later expanded into the study of extracellular vesicles across species. His educational journey was characterized by a consistent focus on translational research, integrating bench-side discovery with real-world applications. Francisco’s advanced training in biomedical sciences forms the cornerstone of his research career, laying a foundation for his subsequent innovations in immunogenic vesicle technologies.

Experience

Francisco Sierra López currently serves as a guest researcher at the High Specialty Regional Hospital of Ixtapaluca (HRAEI), where he investigates biomedical applications of extracellular vesicles (EVs). His earlier career includes roles as a doctoral and postdoctoral researcher at CINVESTAV-IPN and UNAM, respectively. Throughout his scientific path, Francisco has designed and led interdisciplinary research projects—particularly those examining extracellular vesicle secretion in pathogenic protozoa, cancerous tissues, and immune cell lines. He has served as principal investigator in four funded research projects and collaborated with various specialists in parasitology, oncology, and cellular biology. Despite having no direct industry collaborations to date, his research findings hold strong potential for clinical and pharmaceutical innovation. Francisco’s work is marked by technical precision and creative experimentation, leading to peer-reviewed publications and internationally recognized patents.

Research Focus

Francisco Sierra López’s research centers on the secretion and application of extracellular vesicles (EVs) across a spectrum of biological contexts, from protozoan parasitology to immunology and oncology. He has conducted experimental studies on EVs secreted by protozoan parasites, such as Entamoeba histolytica and Acanthamoeba culbertsoni, elucidating their roles in host-pathogen interactions. His work also extends to understanding EVs in cancer cells (including ovarian cancer and leukemia) and immune cells (monocytes, macrophages), particularly under co-infection conditions such as COVID-19. Francisco’s innovative methodologies have led to two patents concerning the purification and immunogenic potential of EVs. His cross-disciplinary approach bridges cellular biology with biomedical application, aiming to transform vesicle biology into actionable health interventions. This research contributes not only to fundamental biology but also to diagnostics, vaccine development, and therapeutic targeting.

Publication Top Notes

1. Influence of Micropatterned Grill Lines on Entamoeba histolytica Trophozoites Morphology and Migration

Authors: F. Sierra-López, L. Baylón-Pacheco, et al.
Journal: Frontiers in Cellular and Infection Microbiology, Vol 8, 295, 2018
Cited by: 8
Summary: This study reveals how surface topography influences the morphology and motility of E. histolytica, highlighting the interaction between physical microenvironments and protozoan behavior.

2. Characterization of Low Molecular Weight Protein Tyrosine Phosphatases of Entamoeba histolytica

Authors: F. Sierra-López, L. Baylón-Pacheco, SC Vanegas-Villa, JL Rosales-Encina
Journal: Biochimie, Vol 180, pp. 43–53, 2021
Cited by: 5
Summary: This biochemical investigation characterizes phosphatases in E. histolytica, offering insight into potential enzymatic targets for therapeutic intervention in amoebiasis.

3. Extracellular Vesicles Secreted by Acanthamoeba culbertsoni Have COX and Proteolytic Activity and Induce Hemolysis

Authors: F. Sierra-López, I. Castelan-Ramírez, D. Hernández-Martínez, et al.
Journal: Microorganisms, Vol 11(11), Article 2762, 2023
Cited by: 3
Summary: The paper explores enzymatic activities within EVs secreted by A. culbertsoni, showing their role in red blood cell lysis and pathogenicity mechanisms.

4. A Fraction of Escherichia coli Bacteria Induces an Increase in the Secretion of Extracellular Vesicle Polydispersity in Macrophages

Authors: SMM Sierra-López F, Iglesias-Vázquez V, et al.
Journal: International Journal of Molecular Sciences, Vol 26(8), 2025
Summary: This upcoming article discusses how bacterial co-infection alters EV secretion profiles in immune cells, with implications for inflammation and viral pathogenesis.

Patents

1. Immunogenic Giant Extracellular Vesicles of Parasitic Protozoa

Patent No.: MX/a/2016/014875 | IMPI | Issued: March 22, 2023
Folio: MX/E/2016/081517
Inventors: Francisco Sierra López, Luis A. Carreño Sánchez, José L. Rosales Encina
Patent Link (IMPI)

2. Same Patent Filed at WIPO

Folio: PCT/IB2017/056917 | Published: June 17, 2018
Patent Link (WIPO)

Conclusion

Dr. Francisco Sierra López stands out as a high-potential early-career researcher whose innovative work on extracellular vesicles spans a rare combination of protozoan pathogenesis, cancer biology, and immunology. His cross-disciplinary research, patented technologies, and early scholarly impact indicate a trajectory toward excellence in biomedical science.

Donglin Ren | Medical Application | Best Researcher Award

Prof. Dr Donglin Ren | Medical Application | Best Researcher Award

Professor, The Sixth Affiliated Hospital, Sun Yat-sen University, China

Professor Dong-Lin Ren is a renowned expert in colorectal surgery, specializing in the integration of Traditional Chinese Medicine (TCM) and Western Medicine for anorectal and pelvic floor disorders. He holds multiple esteemed positions, including Chief Consultant at the Department of Colorectal Surgery at the Sixth Affiliated Hospital of Sun Yat-sen University. As a professor at Sun Yat-sen University and a mentor to doctoral and postdoctoral candidates, he has made significant contributions to both clinical practice and medical education. With over 250 peer-reviewed publications and more than 20 patents, his work spans innovative surgical techniques, minimally invasive treatments for colorectal tumors, and reconstructive surgeries. Professor Ren’s leadership in professional societies and his pioneering work in complex anorectal disease management have earned him national recognition as a leading medical talent. His dedication to advancing healthcare makes him a key figure in both the medical and academic communities.

Profile

Scopus

Strengths for the Award

  1. Extensive Academic and Research Contributions:
    • Publications: Professor Ren has published over 250 peer-reviewed articles, including over 50 in high-impact SCI journals. His work contributes significantly to the fields of colorectal surgery, anorectal diseases, and the integration of Traditional Chinese Medicine with Western Medicine.
    • Research Leadership: He has led or participated in more than 10 national or provincial research projects, showcasing his leadership and dedication to advancing medical research.
    • Innovative Patents: Professor Ren holds over 20 national invention and utility model patents, underlining his commitment to creating new solutions in the medical field.
  2. Clinical Expertise:
    • His clinical work on complex colorectal and anal diseases, including advanced techniques like NOSES for low rectal cancer and minimally invasive treatments for anorectal disorders, has set new standards in the field. This directly influences his research on treatment outcomes and surgical innovations.
  3. Multidisciplinary Approach:
    • Professor Ren’s integration of Traditional Chinese Medicine (TCM) and Western Medicine is a unique approach that enriches his research perspective. This not only brings innovation but also opens up new research avenues in integrative medicine.
  4. Teaching and Mentorship:
    • As a professor and doctoral/postdoctoral supervisor, his impact on the next generation of researchers is substantial. His role in educating and mentoring budding medical professionals enhances the depth and longevity of his contributions to the medical field.
  5. Recognition and Influence:
    • Professor Ren has received notable awards, including the title of Leading Medical Talent in Guangdong Province and China’s National Famous Doctor award. These recognitions underscore his esteemed position within the medical community.
    • His leadership roles in major professional societies and committees further establish him as a key figure in shaping the future of colorectal and pelvic floor surgery.

Areas for Improvement

  1. Broader International Visibility:
    • While Professor Ren is highly influential within China, his international visibility could be expanded. Greater engagement in global collaborations and international research networks would amplify the global impact of his work.
  2. Public Outreach of Research Findings:
    • Although Professor Ren has published numerous articles, more efforts could be made to translate his findings into practical guidelines for healthcare professionals globally. This would help to disseminate his innovative approaches to a broader audience.
  3. Focus on Translational Research:
    • While his work is highly clinical, more focus on the translational aspects (such as moving research from the bench to bedside more rapidly) could make his contributions even more impactful.

Education

Professor Dong-Lin Ren earned his medical degree from Sun Yat-sen University, where he further advanced his studies, eventually becoming a Professor of Surgery at the institution. His academic journey is marked by a deep commitment to integrating Traditional Chinese Medicine with Western surgical techniques. Throughout his education, Professor Ren specialized in colorectal surgery, gaining extensive clinical experience in proctology, pelvic floor disorders, and colorectal oncology. He trained under esteemed mentors in both Western and Chinese medicine fields, giving him a unique perspective on patient care. His postdoctoral work focused on minimally invasive procedures for colorectal cancer and complex anal diseases. Additionally, Professor Ren has trained and mentored numerous doctoral and postdoctoral candidates in surgical research, integrating his knowledge of both Eastern and Western medicine. His continuous pursuit of higher education and research excellence has positioned him as a leading figure in his field, influencing medical practices globally.

Experience

Professor Dong-Lin Ren has an extensive career in both clinical practice and academia. He is the Chief Consultant and Director at the Department of Colorectal Surgery, Department of Integrated Traditional Chinese and Western Medicine for Anorectal Surgery, and Pelvic Floor Center at the Sixth Affiliated Hospital of Sun Yat-sen University. In addition to his clinical expertise, he served as Vice President and Operation Director at the hospital, and is the Dean of the School of Pelvic Floor Anorectal Surgery. His experience spans advanced surgical procedures, including minimally invasive treatments for colorectal cancer and the integration of Traditional Chinese Medicine (TCM) with Western approaches. Professor Ren also leads a team performing the largest number of anorectal procedures in China, specializing in managing complex conditions like recurrent anal fistulas and rectal prolapse. He has guided and mentored numerous doctors, shaping the future of colorectal surgery both domestically and internationally.

Awards and Honors

Professor Dong-Lin Ren has received numerous prestigious awards and honors throughout his career. He is recognized as a Leading Medical Talent in Guangdong Province and was the third recipient of China’s National Famous Doctors award, a testament to his excellence in both clinical practice and medical research. His contributions to the field of colorectal surgery have earned him leadership roles in various professional societies. Professor Ren is the Chairman of the Asia Alliance of Colorectal and Pelvic Floor Disorders and holds significant positions in other medical organizations, such as the China Geriatric Health Care Association and the Chinese Preventive Medicine Association. He is also honored with several honorary chairman and vice chairman roles in prominent Chinese medical committees. His work has been pivotal in advancing colorectal and pelvic floor medicine, and these recognitions affirm his status as a leading figure in the field.

Research Focus

Professor Dong-Lin Ren’s research focuses on the integration of Traditional Chinese Medicine (TCM) and Western Medicine to develop innovative treatments for colorectal and anorectal diseases. He specializes in the minimally invasive treatment of low rectal cancer, using anus-preserving technologies and NOSES techniques to avoid abdominal and pelvic incisions. His research includes complex conditions like anal fistulas, chronic constipation, rectovaginal fistulas, and recurrent rectal cancer. He has led or participated in multiple national research projects, contributing to the development of MRI-based deep learning classifiers and other diagnostic tools. Additionally, his work on single-cell RNA sequencing and the effects of astragaloside IV in colorectal cancer treatment has made significant advancements in understanding cellular dynamics and therapeutic interventions. Professor Ren’s research efforts aim to improve both patient outcomes and the effectiveness of surgical and non-surgical treatments in colorectal diseases.

Publication Top Notes

  1. “Development and validation of the MRI-based deep learning classifier for distinguishing perianal fistulizing Crohn’s disease from cryptoglandular fistula: a multicenter cohort study” 🧠📚
  2. “Single-cell transcriptome analysis reveals immunosuppressive landscape in overweight and obese colorectal cancer” 🧬⚖️
  3. “Single-cell RNA sequencing reveals cellular dynamics and therapeutic effects of astragaloside IV in slow transit constipation” 🧬💊
  4. “Evaluation of transrectal ultrasound-guided tru-cut biopsy as a complementary method for predicting pathological complete response in rectal cancer after neoadjuvant treatment” 🔬📈
  5. “Stapled transperineal rectovaginal fistula repair for low- and mid-level rectovaginal fistulas: A comparison study with rectal mucosal advancement flap repair” 🔪🩺
  6. “Preoperative assessment of fistula-in-ano using SonoVue enhancement during three-dimensional transperineal ultrasound” 🔬📸
  7. “A magnetic resonance imaging-based decision-making tool for predicting complex anal fistulas healing in the early postoperative period” 🧠💡
  8. “Cancer-associated fibroblasts undergoing neoadjuvant chemotherapy suppress rectal cancer revealed by single-cell and spatial transcriptomics” 🧬💔
  9. “Unraveling dynamic interactions between tumor-associated macrophages and consensus molecular subtypes in colorectal cancer: An integrative analysis of single-cell and bulk RNA transcriptome” 🔬🦠
  10. “Should the diverting enterostomy for refractory anorectal Crohn’s disease be considered in advance?” 💡🌱

Conclusion

Professor Dong-Lin Ren is a highly suitable candidate for the Best Researcher Award. His contributions to both clinical practice and research are substantial and have led to groundbreaking advancements in colorectal and anorectal surgery. His leadership in integrating Traditional Chinese Medicine with Western practices provides a unique and innovative approach that benefits both patient care and medical research. With his continued impact on the medical community through teaching, research, and clinical excellence, Professor Ren’s work is deserving of recognition on an international level. Expanding his global research network and increasing public outreach could further solidify his standing as a leader in medical research.