Francisco Sierra Lopez | Medicine and Health Sciences | Best Researcher Award

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Dr. Francisco Sierra Lopez| Medicine and Health Sciences | Best Researcher Award

Guest researcher, High Specialty Regional Hospital of Ixtapaluca (HRAEI), Mexico

Francisco Sierra López is a guest researcher at the High Specialty Regional Hospital of Ixtapaluca (HRAEI), Mexico. A molecular biologist and biomedical innovator, he specializes in the study of extracellular vesicles and their role in infections, cancer, and immunological processes. He received his Bachelor’s in Biology and completed postdoctoral research at the National Autonomous University of Mexico (UNAM), followed by a Master’s and Ph.D. in Science from the Center for Research and Advanced Studies (CINVESTAV-IPN). His interdisciplinary approach led to the discovery and patenting of immunogenic giant extracellular vesicles (VEGs) derived from protozoan parasites. Francisco has authored four internationally recognized publications and is credited with both a national and a WIPO-registered patent. His research continues to explore novel diagnostic and therapeutic avenues in oncology and infectious diseases.

Profile

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Education

Francisco Sierra López holds a Bachelor of Science in Biology and pursued his postdoctoral training at the National Autonomous University of Mexico (UNAM), one of Latin America’s most prestigious research institutions. He earned his Master’s and Doctorate degrees in Science from the Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN), specializing in cell and molecular biology. During his academic tenure, he engaged in groundbreaking studies on protozoan parasites and molecular signaling, which later expanded into the study of extracellular vesicles across species. His educational journey was characterized by a consistent focus on translational research, integrating bench-side discovery with real-world applications. Francisco’s advanced training in biomedical sciences forms the cornerstone of his research career, laying a foundation for his subsequent innovations in immunogenic vesicle technologies.

Experience

Francisco Sierra López currently serves as a guest researcher at the High Specialty Regional Hospital of Ixtapaluca (HRAEI), where he investigates biomedical applications of extracellular vesicles (EVs). His earlier career includes roles as a doctoral and postdoctoral researcher at CINVESTAV-IPN and UNAM, respectively. Throughout his scientific path, Francisco has designed and led interdisciplinary research projects—particularly those examining extracellular vesicle secretion in pathogenic protozoa, cancerous tissues, and immune cell lines. He has served as principal investigator in four funded research projects and collaborated with various specialists in parasitology, oncology, and cellular biology. Despite having no direct industry collaborations to date, his research findings hold strong potential for clinical and pharmaceutical innovation. Francisco’s work is marked by technical precision and creative experimentation, leading to peer-reviewed publications and internationally recognized patents.

Research Focus

Francisco Sierra López’s research centers on the secretion and application of extracellular vesicles (EVs) across a spectrum of biological contexts, from protozoan parasitology to immunology and oncology. He has conducted experimental studies on EVs secreted by protozoan parasites, such as Entamoeba histolytica and Acanthamoeba culbertsoni, elucidating their roles in host-pathogen interactions. His work also extends to understanding EVs in cancer cells (including ovarian cancer and leukemia) and immune cells (monocytes, macrophages), particularly under co-infection conditions such as COVID-19. Francisco’s innovative methodologies have led to two patents concerning the purification and immunogenic potential of EVs. His cross-disciplinary approach bridges cellular biology with biomedical application, aiming to transform vesicle biology into actionable health interventions. This research contributes not only to fundamental biology but also to diagnostics, vaccine development, and therapeutic targeting.

Publication Top Notes

1. Influence of Micropatterned Grill Lines on Entamoeba histolytica Trophozoites Morphology and Migration

Authors: F. Sierra-López, L. Baylón-Pacheco, et al.
Journal: Frontiers in Cellular and Infection Microbiology, Vol 8, 295, 2018
Cited by: 8
Summary: This study reveals how surface topography influences the morphology and motility of E. histolytica, highlighting the interaction between physical microenvironments and protozoan behavior.

2. Characterization of Low Molecular Weight Protein Tyrosine Phosphatases of Entamoeba histolytica

Authors: F. Sierra-López, L. Baylón-Pacheco, SC Vanegas-Villa, JL Rosales-Encina
Journal: Biochimie, Vol 180, pp. 43–53, 2021
Cited by: 5
Summary: This biochemical investigation characterizes phosphatases in E. histolytica, offering insight into potential enzymatic targets for therapeutic intervention in amoebiasis.

3. Extracellular Vesicles Secreted by Acanthamoeba culbertsoni Have COX and Proteolytic Activity and Induce Hemolysis

Authors: F. Sierra-López, I. Castelan-Ramírez, D. Hernández-Martínez, et al.
Journal: Microorganisms, Vol 11(11), Article 2762, 2023
Cited by: 3
Summary: The paper explores enzymatic activities within EVs secreted by A. culbertsoni, showing their role in red blood cell lysis and pathogenicity mechanisms.

4. A Fraction of Escherichia coli Bacteria Induces an Increase in the Secretion of Extracellular Vesicle Polydispersity in Macrophages

Authors: SMM Sierra-López F, Iglesias-Vázquez V, et al.
Journal: International Journal of Molecular Sciences, Vol 26(8), 2025
Summary: This upcoming article discusses how bacterial co-infection alters EV secretion profiles in immune cells, with implications for inflammation and viral pathogenesis.

Patents

1. Immunogenic Giant Extracellular Vesicles of Parasitic Protozoa

Patent No.: MX/a/2016/014875 | IMPI | Issued: March 22, 2023
Folio: MX/E/2016/081517
Inventors: Francisco Sierra López, Luis A. Carreño Sánchez, José L. Rosales Encina
Patent Link (IMPI)

2. Same Patent Filed at WIPO

Folio: PCT/IB2017/056917 | Published: June 17, 2018
Patent Link (WIPO)

Conclusion

Dr. Francisco Sierra López stands out as a high-potential early-career researcher whose innovative work on extracellular vesicles spans a rare combination of protozoan pathogenesis, cancer biology, and immunology. His cross-disciplinary research, patented technologies, and early scholarly impact indicate a trajectory toward excellence in biomedical science.

Davood Zare | Biotechnology | Best Researcher Award

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Assist Prof Dr Davood Zare | Biotechnology | Best Researcher Award

Scientific board, Iranian Research Organization for Science and Technology, Iran

Davood Zare, born on May 21, 1970, in Karaj, Iran, is a distinguished microbiologist with over two decades of experience in biotechnology. He has held significant roles, including Head of Biotechnology Laboratories and Deputy of the Biotechnology Department at the Iranian Research Organization for Science & Technology (IROST). Davood is a prolific researcher and educator, with a strong commitment to advancing the field of food biotechnology and microbial research. His work emphasizes sustainable practices and the development of innovative bioproducts. He is fluent in Farsi and English and has contributed significantly to various scientific committees and educational institutions.

Profile

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Strengths for the Award 

  1. Extensive Educational Background:
    • Dr. Zare holds multiple advanced degrees in microbiology and biotechnology from reputable institutions, including a PhD from University Putra Malaysia.
  2. Rich Research Experience:
    • With over two decades of experience in various aspects of biotechnology, Dr. Zare has participated in significant research projects, contributing both as an executive and assistant researcher.
    • His work spans diverse topics, including enzyme production, microbial fermentation, and food biotechnology, showcasing a broad expertise that is crucial for innovative research.
  3. Proven Publication Record:
    • Dr. Zare has published numerous articles in respected scientific journals, reflecting a strong contribution to his field. His publications cover a variety of topics and demonstrate his ongoing commitment to advancing knowledge in food biotechnology and microbiology.
  4. Leadership and Administrative Roles:
    • He has held multiple leadership positions, including Head of Biotechnology Pilot Plant and Deputy of Department of Biotechnology at IROST. His experience in administrative roles illustrates his capability to lead and manage research initiatives effectively.
  5. Teaching and Mentorship:
    • Dr. Zare’s teaching experience at various academic institutions demonstrates his dedication to education and the transfer of knowledge to the next generation of scientists. He has mentored PhD and MSc students, contributing to the development of future researchers.
  6. Engagement in Scientific Communities:
    • His role as a scientific adviser and participation in various committees related to biotechnology awards reflects his active engagement and recognition within the scientific community.

Areas for Improvement

  1. Diversification of Research Collaborations:
    • While Dr. Zare has an extensive background in biotechnology, expanding collaborations with international researchers could enhance the scope and impact of his research projects.
  2. Innovation in Research Approaches:
    • Continued exploration of cutting-edge technologies and methodologies could further enhance his research outputs. Engaging in interdisciplinary research may also yield innovative results.
  3. Public Outreach and Dissemination:
    • Increasing efforts in public outreach and science communication could enhance the societal impact of his research. Engaging with broader audiences may help in promoting the importance of biotechnology.

Education

Davood Zare holds a B.Sc. in Microbiology (1993) and an M.Sc. in Bacteriology (1996) from Tehran University and Pasteur Institute of Iran, respectively. He earned his PhD in Food Biotechnology from University Putra Malaysia in 2013. His academic journey is characterized by a rigorous focus on microbiological research, culminating in significant contributions to both theoretical and practical aspects of the discipline. His education has laid a robust foundation for his subsequent research and teaching endeavors, enabling him to bridge academic knowledge with real-world applications in biotechnology.

Experience

Davood Zare has extensive experience in research and leadership within biotechnology. He has worked as an executive and assistant researcher on various projects at IROST since 1994, focusing on microbial production and bioprocess optimization. He has also held leadership roles, including Head of Biotechnology Pilot Plant and Deputy of the Department of Biotechnology. His teaching experience spans multiple institutions, where he has educated both M.Sc. and Ph.D. students in subjects like Industrial Microbiology and Biotechnology. Davood’s comprehensive experience equips him to address complex challenges in the field of food biotechnology effectively.

Research Focus

Davood Zare’s research focuses on food biotechnology, microbial production, and the optimization of bioprocesses. His work includes the production of microbial proteins, bioplastics, and bioactive compounds from various substrates. He is particularly interested in sustainable practices, utilizing waste materials for bioproduct production, and enhancing microbial fermentation processes. His contributions have significant implications for food safety, quality, and sustainability, making him a key player in advancing biotechnological applications in the food industry.

Publication Top Notes

  • Production of xylanase by Trichoderma longibrachiatum on a mixture of wheat bran and wheat straw: optimization of culture condition by Taguchi method
  • Trans-and cis-urocanic acid, biogenic amine and amino acid contents in ikan pekasam (fermented fish) produced from Javanese carp (Puntius gonionotus) and black tilapia
  • Changes in urocanic acid, histamine, putrescine and cadaverine levels in Indian mackerel (Rastrelliger kanagurta) during storage at different temperatures
  • Assessing the quality of sardine based on biogenic amines using a fuzzy logic model
  • Determination of urocanic acid, a compound implicated in histamine toxicity, and assessment of biogenic amines relative to urocanic acid content in selected fish and fish products
  • Screening of carbon and nitrogen sources using mixture analysis designs for carotenoid production by Blakeslea trispora
  • Production and characterization of poly 3-hydroxybutyrate-co-3-hydroxyvalerate in wheat starch wastewater and its potential for nanoparticle synthesis
  • Determination of trans‐ and cis‐Urocanic Acid in Relation to Histamine, Putrescine, and Cadaverine Contents in Tuna (Auxis Thazard) at Different Storage
  • Hydrogen sulfide removal performance of a bio-trickling filter employing Thiobacillus thiparus immobilized on polyurethane foam under various starvation regimes
  • Synthesis, in vitro and cellular antioxidant activity evaluation of novel peptides derived from Saccharomyces cerevisiae protein hydrolysate: structure–function
  • Development and validation of an ion-pair chromatographic method for simultaneous determination of trans-and cis-urocanic acid in fish samples
  • Isolation, screening and medium optimization of native microalgae for lipid production using nutritional starvation strategy and statistical design
  • Organic acid composition and consumer acceptability of fermented fish produced from black tilapia (Oreochromis mossambicus) and Javanese carp (Puntius gonionotus) using natural
  • Single cell protein production using airlift reactor containing static mixer
  • Production of a mixed fruit juice powder using mixture analysis and a fuzzy model
  • Evaluation of the Physicochemical Characteristics of a Blend Fruit Juice Powder Mixed with Lactiplantibacillus plantarum: A Comparison of Spray Drying and
  • Evaluating the effect of microbial stimulation and oxidative stress on increasing β-Carotene production in Blakeslea trispora

Conclusion

Dr. Davood Zare is an exemplary candidate for the Best Researcher Award. His extensive educational background, rich research experience, and significant contributions to the field of biotechnology, combined with his leadership roles and teaching experience, position him as a leading figure in his area. By addressing areas for improvement, particularly in collaboration and public engagement, he can further enhance his impact and recognition in the scientific community. His work not only advances scientific knowledge but also has practical implications for industries related to food and biotechnology.