Dr. Dermatology Resident., Medical University of South Carolina, United states
Catherine Shirer Barker, MD, is a distinguished dermatology resident at the Medical University of South Carolina. Born and raised in South Carolina, she earned her Bachelor of Science in Biological Sciences with a Spanish minor, graduating Summa Cum Laude from the University of South Carolina Honors College. She pursued a Doctor of Medicine degree at MUSC College of Medicine, completing medical school in May 2023, followed by a preliminary internal medicine year. Her professional journey reflects a consistent commitment to patient care, medical education, and research excellence. Fluent in Spanish, she has worked extensively with underserved populations and volunteered as a medical interpreter, bridging linguistic and cultural gaps in healthcare delivery. Catherine’s multidisciplinary background, linguistic skills, and proactive leadership make her a dynamic early-career physician dedicated to advancing dermatologic care, global health, and health equity.
Professional Profile
Education
Dr. Barker earned her Bachelor of Science in Biological Sciences with a Spanish minor from the University of South Carolina Honors College in 2019, graduating Summa Cum Laude. Her undergraduate thesis examined physician perception of medication nonadherence among diabetic immigrant patients. She then pursued her Doctor of Medicine degree at MUSC College of Medicine, completing medical school in May 2023. Following graduation, she served a preliminary internal medicine residency at MUSC from July 2023 to June 2024, providing a strong internal medicine foundation. Since July 2024 she has been in her dermatology residency at MUSC, scheduled to complete in June 2027. During her training she has maintained certification in Advanced Cardiac Life Support (ACLS) and completed rigorous CITI training covering Good Clinical Practice for behavioral research, biomedical investigators, human subjects protection, and ICH guidelines for investigational trials. This educational pathway reflects her commitment to integrating clinical medicine, research ethics, and specialized dermatologic care.
Research Experience
Dr. Barker’s research portfolio is both broad and impactful. As a medical student at MUSC, she contributed to major dermatopathology research, including a retrospective analysis of 879 direct immunofluorescence (DIF) specimens in bullous diseases, where she demonstrated that n-serrated waves should not exclude bullous lupus and that u-serrated patterns had limited sensitivity for diagnosis. At local free clinics in Charleston, she led a project identifying dermatologic care gaps among uninsured patients, managed IRB applications, surveyed seven clinics, and created a prescribing guide to reduce misdiagnoses. She also co-authored a retrospective study on nurse navigation’s impact on timelines to care in breast pathology, reinforcing the value of improved care coordination. Her undergraduate research addressed diabetic polypharmacy outcomes in hospital stays and explored IL‑33/ST2 pathways in tumorogenesis in murine models. Across these roles, she has been involved in data collection, protocol development, literature review, manuscript writing, IRB applications, and cross-disciplinary collaboration.
Research Focus
Dr. Barker’s primary research interests lie at the intersection of dermatopathology, inflammatory/connective tissue dermatologic disease, and health equity. She is especially focused on serration patterns (u- versus n-serrated) in direct immunofluorescence specimens to refine diagnostic criteria for bullous diseases (e.g., bullous pemphigoid, epidermolysis bullosa acquisita, and bullous lupus). She also investigates practical solutions to improve dermatologic access in underserved populations by implementing teledermatology programs, optimizing prescribing practices in free clinics, and assessing care delivery gaps between primary care providers and specialists. Her work extends to exploring immunomodulatory treatments—such as using dupilumab for actinic prurigo—and dermatologic implications of connective tissue and mycobacterial diseases. Moreover, her interest in global health and equitable access is evident in her outreach to uninsured and immigrant patient groups. Dr. Barker seeks to integrate clinical insights with novel diagnostic and therapeutic pathways to advance skin disease care in both academic and community settings.
Publication Top Notes
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Hudson K, Barker C, Oates J, Williams K. Rheumatologic manifestations in an X-linked chronic granulomatous disease carrier. American Journal of Medical Science. Accepted July 2025.
Summary: Case series exploring autoimmune and rheumatologic features in female carriers of CGD—a novel clinical lens on CGD heterozygosity.
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Sagut P, Lyles E, Vroman J, Barker C, Juratli H, Bruner E, Self S, Elston D. A Comparative Study of Direct Immunofluorescence Patterns in Linear IgA Bullous Dermatosis versus Dermatitis Herpetiformis. American Journal of Dermatopathology. Published November 2024.
Summary: Direct immunofluorescence patterns compared between two blistering disorders to improve differentiation and diagnostic accuracy.
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Barker C, Elston D, Lee K. Generalized Fixed Drug Eruption: A Case Series and Literature Review. Cutis, July 2024.
Summary: Case series of generalized fixed drug eruptions, synthesizing treatment outcomes and literature-based management comparisons.
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Barker C, Elston D. Asymptomatic Erythematous Plaque in an Outdoorsman. Cutis, April 2024.
Summary: Clinical vignette of an outdoor-activity-related dermatologic presentation, highlighting diagnostic considerations.
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Barker C, McGovern TW, Elston DM. Botanical Briefs: Phototoxic Fig Trees. Cutis, April 2024.
Summary: Educational brief describing plant‑induced phototoxic dermatoses related to fig tree exposures.
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Barker C, Sattele L, Strat N, Snyder A, Siegel M, Wine Lee L. Dupilumab as Treatment for Actinic Prurigo. JAAD Case Reports, March 2024.
Summary: Case series documenting success of dupilumab in treating refractory actinic prurigo, offering mechanistic and therapeutic insights.
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Barker C, Bruner E, Self S, Elston D. U‑Serrated and N‑Serrated Patterns in Bullous Pemphigoid, Epidermolysis Bullosa Acquisita, and Bullous Lupus: A Retrospective Observational Study. Journal of the American Academy of Dermatology, Feb 2024.
Summary: Large DIF study examining serrated immunofluorescence patterns to refine diagnostic thresholds for bullous dermatoses—finding n-serration not exclusionary for lupus and low sensitivity of u-serration for bullous lupus.
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Barker C, Alshaikh H, Elston D. Dermatology Practice Updates in Mycobacterial Disease. International Journal of Dermatology, Dec 2023.
Summary: Review article summarizing emerging diagnostic and treatment modalities in dermatologic manifestations of mycobacterial infection.
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Chung C, Barker C, Mukherjee R, et al. The Impact of Nurse Navigation on Timeliness to Treatment for Benign Breast Pathology. Breast Cancer Research and Treatment, Aug 2023.
Summary: Study linking nurse navigation programs with shorter referral-to-treatment intervals in high-risk benign breast lesions.
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Lateef A, Barker C, Snyder A, et al. Adverse events seen with fillers. Dermatology Reviews, July 2023.
Summary: Review of complications associated with cosmetic fillers, with recommendations for prevention and management.
Conclusion
Dr. Catherine Shirer Barker stands out as an exceptionally strong candidate for a Best Researcher Award, particularly in early-career or resident categories. Her work bridges clinical dermatology, social determinants of health, and translational science with notable clarity, productivity, and compassion. With continued trajectory toward independent funding and broader-scale research leadership, she is poised to become a national leader in dermatologic research.