Francisco Sierra Lopez | Medicine and Health Sciences | Best Researcher Award

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Dr. Francisco Sierra Lopez| Medicine and Health Sciences | Best Researcher Award

Guest researcher, High Specialty Regional Hospital of Ixtapaluca (HRAEI), Mexico

Francisco Sierra López is a guest researcher at the High Specialty Regional Hospital of Ixtapaluca (HRAEI), Mexico. A molecular biologist and biomedical innovator, he specializes in the study of extracellular vesicles and their role in infections, cancer, and immunological processes. He received his Bachelor’s in Biology and completed postdoctoral research at the National Autonomous University of Mexico (UNAM), followed by a Master’s and Ph.D. in Science from the Center for Research and Advanced Studies (CINVESTAV-IPN). His interdisciplinary approach led to the discovery and patenting of immunogenic giant extracellular vesicles (VEGs) derived from protozoan parasites. Francisco has authored four internationally recognized publications and is credited with both a national and a WIPO-registered patent. His research continues to explore novel diagnostic and therapeutic avenues in oncology and infectious diseases.

Profile

Google Scholar

Education

Francisco Sierra López holds a Bachelor of Science in Biology and pursued his postdoctoral training at the National Autonomous University of Mexico (UNAM), one of Latin America’s most prestigious research institutions. He earned his Master’s and Doctorate degrees in Science from the Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN), specializing in cell and molecular biology. During his academic tenure, he engaged in groundbreaking studies on protozoan parasites and molecular signaling, which later expanded into the study of extracellular vesicles across species. His educational journey was characterized by a consistent focus on translational research, integrating bench-side discovery with real-world applications. Francisco’s advanced training in biomedical sciences forms the cornerstone of his research career, laying a foundation for his subsequent innovations in immunogenic vesicle technologies.

Experience

Francisco Sierra López currently serves as a guest researcher at the High Specialty Regional Hospital of Ixtapaluca (HRAEI), where he investigates biomedical applications of extracellular vesicles (EVs). His earlier career includes roles as a doctoral and postdoctoral researcher at CINVESTAV-IPN and UNAM, respectively. Throughout his scientific path, Francisco has designed and led interdisciplinary research projects—particularly those examining extracellular vesicle secretion in pathogenic protozoa, cancerous tissues, and immune cell lines. He has served as principal investigator in four funded research projects and collaborated with various specialists in parasitology, oncology, and cellular biology. Despite having no direct industry collaborations to date, his research findings hold strong potential for clinical and pharmaceutical innovation. Francisco’s work is marked by technical precision and creative experimentation, leading to peer-reviewed publications and internationally recognized patents.

Research Focus

Francisco Sierra López’s research centers on the secretion and application of extracellular vesicles (EVs) across a spectrum of biological contexts, from protozoan parasitology to immunology and oncology. He has conducted experimental studies on EVs secreted by protozoan parasites, such as Entamoeba histolytica and Acanthamoeba culbertsoni, elucidating their roles in host-pathogen interactions. His work also extends to understanding EVs in cancer cells (including ovarian cancer and leukemia) and immune cells (monocytes, macrophages), particularly under co-infection conditions such as COVID-19. Francisco’s innovative methodologies have led to two patents concerning the purification and immunogenic potential of EVs. His cross-disciplinary approach bridges cellular biology with biomedical application, aiming to transform vesicle biology into actionable health interventions. This research contributes not only to fundamental biology but also to diagnostics, vaccine development, and therapeutic targeting.

Publication Top Notes

1. Influence of Micropatterned Grill Lines on Entamoeba histolytica Trophozoites Morphology and Migration

Authors: F. Sierra-López, L. Baylón-Pacheco, et al.
Journal: Frontiers in Cellular and Infection Microbiology, Vol 8, 295, 2018
Cited by: 8
Summary: This study reveals how surface topography influences the morphology and motility of E. histolytica, highlighting the interaction between physical microenvironments and protozoan behavior.

2. Characterization of Low Molecular Weight Protein Tyrosine Phosphatases of Entamoeba histolytica

Authors: F. Sierra-López, L. Baylón-Pacheco, SC Vanegas-Villa, JL Rosales-Encina
Journal: Biochimie, Vol 180, pp. 43–53, 2021
Cited by: 5
Summary: This biochemical investigation characterizes phosphatases in E. histolytica, offering insight into potential enzymatic targets for therapeutic intervention in amoebiasis.

3. Extracellular Vesicles Secreted by Acanthamoeba culbertsoni Have COX and Proteolytic Activity and Induce Hemolysis

Authors: F. Sierra-López, I. Castelan-Ramírez, D. Hernández-Martínez, et al.
Journal: Microorganisms, Vol 11(11), Article 2762, 2023
Cited by: 3
Summary: The paper explores enzymatic activities within EVs secreted by A. culbertsoni, showing their role in red blood cell lysis and pathogenicity mechanisms.

4. A Fraction of Escherichia coli Bacteria Induces an Increase in the Secretion of Extracellular Vesicle Polydispersity in Macrophages

Authors: SMM Sierra-López F, Iglesias-Vázquez V, et al.
Journal: International Journal of Molecular Sciences, Vol 26(8), 2025
Summary: This upcoming article discusses how bacterial co-infection alters EV secretion profiles in immune cells, with implications for inflammation and viral pathogenesis.

Patents

1. Immunogenic Giant Extracellular Vesicles of Parasitic Protozoa

Patent No.: MX/a/2016/014875 | IMPI | Issued: March 22, 2023
Folio: MX/E/2016/081517
Inventors: Francisco Sierra López, Luis A. Carreño Sánchez, José L. Rosales Encina
Patent Link (IMPI)

2. Same Patent Filed at WIPO

Folio: PCT/IB2017/056917 | Published: June 17, 2018
Patent Link (WIPO)

Conclusion

Dr. Francisco Sierra López stands out as a high-potential early-career researcher whose innovative work on extracellular vesicles spans a rare combination of protozoan pathogenesis, cancer biology, and immunology. His cross-disciplinary research, patented technologies, and early scholarly impact indicate a trajectory toward excellence in biomedical science.

Uday Muddapur | Environmental and Biomedical | Outstanding Scientist Award

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Dr. Uday Muddapur | Environmental and Biomedical | Outstanding Scientist Award

Professor,KLE Technological Univeristy,India

Dr. Uday M. Muddapur’s curriculum vitae reflects an accomplished academic and research profile in the field of biotechnology and biochemistry. As a Professor in the Department of Biotechnology at KLE Technological University, Hubballi, he holds a Ph.D. in Biochemistry from the Department for Postgraduate Studies in Biochemistry at Karnatak University, Dharwad. His doctoral research focused on fungal transformation of Δ3-Carene, fungal amylase, and fungal pigments.

Profile:

Academic Qualifications:

  • Ph.D. in Biochemistry, Karnatak University, Dharwad, 2004.
  • M.Sc. in Biochemistry, Karnatak University, Dharwad, 1999.

Research and Fellowship:

  • Dr. Muddapur has guided several doctoral students, focusing on areas such as drug designing for tuberculosis, biosynthesis of nanoparticles, and evaluation of biomarkers for diseases like lymphatic filariasis.
  • He has been awarded multiple research honors, including “Project of the Year” by KSCST and the “Outstanding Scientist Award” at the INSO International Scientist Awards in 2022.

Teaching and Online Education:

  • Dr. Muddapur has taught subjects such as Biochemistry, Microbiology, Enzyme Technology, and Biotechnology. Additionally, he has completed several online courses related to biochemical energy metabolism, drug discovery, immunology, and bioinformatics.

Research Interests:

His research interests lie in areas such as:

  • Drug discovery and development.
  • Nanotechnology applications, including the synthesis and characterization of nanoparticles.
  • Microbial biotechnology and bioremediation.
  • Biomedical applications of bioactive compounds.

Publications:

Dr. Muddapur has authored multiple journal articles in reputable scientific publications. Some of his recent works include studies on the biomedical uses of phytochemicals, antimicrobial properties of nanoparticles, and the bioremediation of plastics by fungi.

Professional Links:

  • ORCID: 0000-0003-3463-1989
  • Scopus ID: 55773089600
  • Google Scholar ID: Zwn4E-kAAAAJ

Previous Positions:

  • Professor at KLE Technological University, Hubballi (since 2016).
  • Professor at KLE Society’s College of Engineering and Technology, Belgaum (2005-2016).
  • Lecturer at Pooja Bhagavat Memorial Mahajana Post Graduate Centre, Mysore (2004-2005).

Dr. Muddapur’s work spans diverse areas of biochemistry and biotechnology, with a significant contribution to research and academia, especially in bioactive compound development and nanomedicine.

Prof. Dr. Tsonko Kolev | Medicine and Health Sciences | Best Researcher Award

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Prof. Dr. Tsonko Kolev | Medicine and Health Sciences | Best Researcher Award

Prof. Dr. Tsonko Kolev, Institute of Molecular Biology, Bulgarian Academy of Sciences, Bulgaria

Prof. Dr. Tsonko Kolev is a distinguished Bulgarian scientist specializing in organic chemistry, structural organic analysis, and vibrational spectroscopy. He is known for his extensive work in X-ray analysis, DFT calculations, IR, Raman, and UV-vis spectroscopy, focusing on organic compounds and materials. Prof. Kolev has contributed significantly to the understanding of stilbazolium dyes and solvatochromism. Throughout his career, he has collaborated on numerous international projects, and his work has been published in prestigious journals. He has received the National Award for The Prominent Scientist in the Field of Natural Sciences “Pitagor” in 2011. With over 50 published works, Prof. Kolev is a highly respected figure in the scientific community, particularly in the study of structural chemistry and spectroscopy, which are critical to advancing applications in material science, medicinal chemistry, and environmental monitoring.

Profile

Education

Prof. Dr. Tsonko Kolev completed his undergraduate studies in organic chemistry at Sofia University, Bulgaria, where he graduated with a Master’s degree from the Faculty of Chemistry in 1971. He further pursued his academic career by leading research and contributing to scientific advancements in organic chemistry. With a solid foundation in the theoretical and experimental aspects of chemistry, his work has significantly influenced the study of structural organic analysis and spectroscopy. Throughout his career, Prof. Kolev has received multiple awards, including the “Pitagor” award in 2011, solidifying his reputation in the academic community. His research interests include molecular structure, interaction of organic compounds with light, and the application of vibrational spectroscopy. Prof. Kolev’s academic journey reflects both his commitment to fundamental scientific inquiry and his desire to apply this knowledge to practical problems in chemistry and material science.

Experience

Prof. Dr. Tsonko Kolev has an illustrious academic career, marked by his role as Group Leader in Structural Organic Analysis from 1992 to 2005 at the Bulgarian Academy of Sciences. During his tenure, he led numerous high-impact research projects focused on spectroscopic analysis and molecular structure determination. His professional activities extend beyond academia, having contributed extensively to the development of spectroscopic techniques, X-ray diffraction, and DFT calculations, especially in the study of organic dyes and solvatochromism. Prof. Kolev’s leadership is evident in his collaborations with universities, research institutes, and international conferences, where he frequently shares his knowledge on vibrational spectroscopy and crystallography. In recognition of his contributions to natural sciences, he was awarded the prestigious “Pitagor” National Award in 2011. Throughout his career, he has mentored numerous young scientists and contributed to advancing the understanding of the structural properties of organic compounds in applied chemistry.

Research Focus

Prof. Dr. Tsonko Kolev’s research primarily revolves around the structural and spectroscopic analysis of organic compounds. His work integrates X-ray analysis, DFT calculations, and vibrational spectroscopy (IR, Raman, and UV-vis) to investigate the molecular properties of stilbazolium dyes and solvatochromic materials. His studies aim to unravel the electronic structures, interactions, and environmental factors influencing the behavior of these compounds in various media. Additionally, Prof. Kolev explores the synthesis and characterization of organic materials, particularly focusing on the molecular interactions that can influence the performance of organic semiconductors and dyes. He is also deeply involved in applying these techniques to fields such as material science, medicinal chemistry, and environmental monitoring. His interdisciplinary approach to chemistry has led to key advancements in understanding the relationship between molecular structure and the optical properties of organic compounds, contributing to the development of novel functional materials for diverse applications.

Publication Top Notes

  • Crystal Structures, Molecular Docking and In Vitro Investigations of Two 4-Substituted 2-(5,5-dimethyl-3-styrylcyclohex-2-enylidene)malononitrile Derivatives as Potential Topoisomerase II Inhibitors (2024) 🧬🧪
  • Application of Vibrational Spectroscopy and XRD Analysis for Investigation of Calcium Oxalate Kidney Stones (2019) 💎🔬
  • Preparation and Spectral Properties of Europium Hydrogen Squarate Microcrystals (2018) 💠🔍
  • Comparing of the Crystal Structure and Spectroscopic Properties of Some Stilbazolium Dyes with Enlarged π-Conjugated System I. Chromophores with p-Dimethylamino Group (2017) 🔶📏
  • Prolinamide Containing Diamides of Squaric Acid – Synthesis and Structural Characterization (2017) ⚗️🧬
  • Syntheses, Structure and Physico-Chemical Properties of Mono-Squaramides (2017) 🔬🧪
  • New Structural Motif of Hydrogensquarate Anions in the Presence of dl-Serinium Cation. Spectral and Structural Elucidation (2015) 🔍🧬
  • The 1:1 Proton-Transfer Compounds of N,N-Dimethyl-4-[(E)-2-(4-Pyridinyl)Vinyl]Aniline with 3-Nitrophthalic and Perchloric Acids (2015) 🧪🧬
  • Synthesis, Crystal Structure, and Spectroscopic Properties of New Stilbazolium Salt with Enlarged π-Conjugated System (2013) 🧪🔬
  • Novel Styrylquinolinium Dye Thin Films Deposited by Pulsed Laser Deposition for Nonlinear Optical Applications (2012) 💡🧪
  • 2-(Phenylethyl)Ammonium Hydrogensquarate Hemihydrate: Crystal Structure, Solid-State IR-Spectroscopic and Theoretical Characterization (2010) 🧬💡
  • Crystal Structure and Spectroscopic Elucidation of 3-Phenylpyridinium Hydrogensquarate (2010) 🔬🧪
  • New Au(III), Pt(II) and Pd(II) Complexes with Pentapeptide Glycylglycyl-L-Methyonyl-Glycyl-Glycine and Their Interaction with Calf Thymus DNA (2010) 🧬🧪