Emily Sabo | Biochemistry | Best Researcher Award

Dr. Emily Sabo | Biochemistry | Best Researcher Award

Previous Student, Colorado School of Mines, United States

Dr. E.T. Sabo is a graduate student at Colorado School of Mines, pursuing a Ph.D. in Applied Chemistry under the mentorship of Dr. Richard Holz. Their research focuses on the sulfur mobilization mechanisms for Fe-S cluster biosynthesis in Staphylococcus aureus, aiming to uncover critical insights into bacterial biochemistry and potential antibiotic targets. With a solid background in chemical and biochemical techniques, Dr. Sabo has developed expertise in protein purification, enzyme kinetics, crystallography, and computational modeling. Throughout their career, they have mentored undergraduate and high school students, participated in outreach programs, and contributed to community-building efforts within the academic environment. With multiple publications and presentations in leading journals and conferences, Dr. Sabo is recognized for their scientific acumen, leadership, and passion for advancing biochemistry.

Profile

Education

Dr. E.T. Sabo is currently completing a Ph.D. in Applied Chemistry at Colorado School of Mines (Aug 2019–Dec 2024), under the supervision of Dr. Richard Holz. Their dissertation explores the sulfur mobilization mechanisms for Fe-S cluster biosynthesis in Staphylococcus aureus, an area of great interest for antimicrobial research. Prior to their graduate studies, Dr. Sabo earned a B.S. in Chemistry with a minor in Mathematics from the University of Georgia (Aug 2015–May 2019). This foundational training set the stage for their extensive work in biochemistry and molecular biology, equipping them with a deep understanding of both chemical and biological systems. The combination of rigorous academic training and hands-on research experience allows Dr. Sabo to bridge the gap between theoretical chemistry and practical laboratory applications in their work on sulfur biochemistry and enzyme function.

Experience

Dr. Sabo’s research experience includes a diverse set of skills in applied chemistry and biochemistry. As a Graduate Research Assistant at Colorado School of Mines (2020–2024), Dr. Sabo focused on studying sulfur mobilization in bacterial enzymes, such as cysteine desulfurases. This involved advanced techniques such as protein purification, enzyme kinetics, protein crystallography, and computational docking. Notably, they developed assays for high-throughput screening (HTS) to study enzyme inhibition and optimized crystallography screens for structural analysis. Additionally, Dr. Sabo has significant experience with UV-Vis and EPR spectroscopy and molecular modeling, crucial tools in biochemistry research. Their undergraduate experience at the University of Georgia (2015–2019) also involved working on mass spectrometry-based analyses of glycan metabolites in human kidney cells, further strengthening their broad skillset. Dr. Sabo has consistently demonstrated an ability to mentor and collaborate with students, as well as present complex research findings at conferences.

Awards and Honors

Dr. E.T. Sabo has earned several accolades recognizing their outstanding contributions to research and academics. They received the Mines GRADS Best Oral Talk award in March 2024, securing 2nd place in Biological, Health, and Social Sciences. Their work was recognized for its depth and clarity in communicating complex scientific concepts. Dr. Sabo also received the prestigious ACS travel award in August 2022, facilitating their participation in the American Chemical Society’s Division of Inorganic Chemistry conference. As an undergraduate, Dr. Sabo was awarded the Classic Scholar Award at the University of Georgia, which acknowledged their academic excellence. Their dedication to advancing scientific understanding and contributing to the academic community has been instrumental in the recognition they’ve received. These honors highlight Dr. Sabo’s growing reputation as an emerging leader in the field of applied chemistry and biochemistry, especially in the study of bacterial biochemistry.

Research Focus

Dr. E.T. Sabo’s research is focused on understanding sulfur mobilization mechanisms for Fe-S cluster biosynthesis in Staphylococcus aureus, a critical process for bacterial survival and virulence. By studying the cysteine desulfurase complex in this pathogenic bacterium, Dr. Sabo aims to uncover potential targets for novel antimicrobial therapies. Their work delves into enzyme kinetics, protein-protein interactions, and the structural characterization of sulfur transfer pathways, with the goal of improving our understanding of microbial biochemistry. The research also extends to the study of small molecule inhibitors and their effect on sulfur metabolism, which could offer insights into the development of new antibiotic strategies. Additionally, Dr. Sabo is exploring computational approaches to model protein-ligand interactions, further enhancing the ability to predict and design compounds that interfere with sulfur cluster biosynthesis. This interdisciplinary approach promises to advance both basic biochemistry and applied pharmaceutical research.

Publications

  1. Boncella, A. E.; Sabo, E. T.; Santore, R. M.; Carter, J.; Whalen; Hudspeth, J. D.; Morrison, C. N. “The expanding utility of iron-sulfur clusters: Their functional roles in biology, synthetic small molecules, maquettes and artificial proteins, biomimetic materials, and therapeutic strategies.” Coordination Chemistry Reviews, 453, 2022. 🔬⚛️
  2. Hudspeth, J.D.; Boncella, A. E.; Sabo, E. T.; Andrews, T.; Boyd, J.; Morrison, C.N. “Structural and Biochemical Characterization of the Cysteine Desulfurase Complex SufSU.” ACS Omega, 7(48), 44124-44133, 2022. 🧬🧪
  3. Sabo, E.T. and Nelson, C.; Stark, V.; Aasman, K.; Boyd, J.; Holz, R. “Practical Spectrophotometric Assay for the Cysteine Desulfurase SufS from Staphylococcus aureus, a Potential Antibiotic Target.” Antibiotics. Accepted. 💊🦠
  4. Sabo, E.T.; Gerlich, G.; Nelson, C.; Stark, V.; Aasman, K.; Morrison, C.; Boyd, J.; Holz, R. “Kinetic Analysis of Cysteine Desulfurase SaSufS from Staphylococcus aureus.” In preparation. 🧑‍🔬🔎
  5. Sabo, E.T., Nelson, C.; Bennet, B.; Holz, R. “Cobalt Substitution of the Zinc-dependent Sulfur Transferase SaSufU from Staphylococcus aureus.” In preparation. ⚙️💡

 

 

Prof. Suresh Kumar Thallapuranam | Biochemistry | Best Researcher Award

Prof. Suresh Kumar Thallapuranam | Biochemistry | Best Researcher Award

Mildred Cooper Chair of Biochemistry & Bioinformatics, University of AArkansas, United States

Prof. Suresh Kumar Thallapuranam is a distinguished academic and researcher in the field of biochemistry and bioinformatics. Born on February 2, 1961, he obtained his Ph.D. from Osmania University, Hyderabad, India, in 1993. Prof. Thallapuranam’s career spans multiple international institutions, including the Center for Cellular & Molecular Biology in India, National Tsing Hua University in Taiwan, and the University of Arkansas. His research contributions in protein folding, bioactive peptides, and structural bioinformatics have earned him recognition in the scientific community. He is currently a professor and holds the Mildred B. Cooper Endowed Chair of Bioinformatics at the University of Arkansas. His work focuses on understanding molecular mechanisms and protein interactions with various applications in health and disease.

Profile

Education

Prof. Suresh Kumar Thallapuranam completed his undergraduate and postgraduate studies in India before pursuing a Ph.D. in Biochemistry at Osmania University, Hyderabad, in 1993. His doctoral research laid the foundation for his expertise in molecular biology and structural bioinformatics. After completing his Ph.D., he embarked on an international academic journey, serving as a research scientist at the Center for Cellular & Molecular Biology in Hyderabad from 1991-1994. His postdoctoral work at National Tsing Hua University in Taiwan solidified his interest in protein folding, molecular interactions, and structural biology. Prof. Thallapuranam’s academic achievements continued at the University of Arkansas, where he has grown his career from a research assistant professor to a full professor. His research contributions and teaching excellence have made him a prominent figure in both the academic and scientific communities.

Experience

Prof. Suresh Kumar Thallapuranam has a rich and varied academic career that spans over three decades. From 1991 to 1994, he served as a research scientist at the Center for Cellular & Molecular Biology in India, focusing on molecular biology and protein studies. In 1994, he moved to Taiwan, where he worked as a research associate and later as a staff scientist at National Tsing Hua University until 2003. In 2003, he joined the University of Arkansas as a research assistant professor and progressively advanced through academic ranks. He has been an assistant professor (2006-2010), an associate professor (2010-2015), and since 2015, a full professor. Prof. Thallapuranam is also the Director of the Office of Undergraduate Research at the University of Arkansas since 2020. His research interests cover protein structure, folding, and bioinformatics, with significant contributions to understanding the molecular mechanisms in various health-related proteins.

Awards and Honors

Prof. Suresh Kumar Thallapuranam has received numerous awards and recognitions for his outstanding contributions to research and teaching. His excellence in mentoring and teaching was acknowledged through the Honors College Outstanding Mentor Award from 2007 to 2023. He received the Robert C. and Sandra Connor Fellowship in 2008 for outstanding research and teaching, and in 2010, he was honored with the Faculty Gold Medal from the Chancellor’s Office for his exceptional work with undergraduates. In 2015, he was inducted into the University of Arkansas Teaching Academy. Prof. Thallapuranam has been recognized by the National Academy of Inventors in 2017 and received the Charles Nadine Baum University of Arkansas Distinguished Award for Outstanding Teaching in 2018. Other prestigious awards include the Master Teacher Award (2014), Collis Geren Outstanding Interdisciplinary Faculty Award (2020), and the Nolan Faculty Award for outstanding teaching, research, and service in 2023.

Research Focus

Prof. Suresh Kumar Thallapuranam’s research focuses on understanding the molecular mechanisms governing protein folding, interactions, and bioinformatics. His work spans a range of topics, from non-classical secretion of proteins like Interleukin 1α and Fibroblast Growth Factors (FGFs) to investigating the role of cation-pi interactions in protein stability. He is particularly interested in the structure-function relationships of bioactive peptides and the molecular basis of FGF-induced craniosynostosis. Prof. Thallapuranam’s research also delves into the design of drugs targeting FGF-induced pathogenesis and other health-related protein interactions. He collaborates with multiple researchers in various disciplines, including chemistry, biological sciences, and biomedical engineering. Additionally, Prof. Thallapuranam is dedicated to advancing NMR techniques for studying membrane proteins and structural dynamics in complex cellular environments. His interdisciplinary approach connects basic research with potential clinical applications in cancer, viral infections, and tissue regeneration.

Publication Top Notes

  • Polyphenol-induced protein structural modifications in sorghum on pasting properties 🧬📖 (2024)
  • Elucidating the effect of polyphenol-protein interactions on rheological properties of purple waxy rice 🌾🧪 (2024)
  • Molecular Modelling, Synthesis, and In-Vitro Assay to Identify Potential Antiviral Peptides Targeting the 3-Chymotrypsin-Like Protease of SARS-CoV-2 🦠💊 (2023)
  • A meta-analysis of the protein components in rattlesnake venom 🐍🔬 (2021)
  • Silver ions caused faster diffusive dynamics of histone-like nucleoid-structuring proteins in live bacteria ⚡🦠 (2020)
  • Molecular mechanisms of heparin-induced modulation of human interleukin 12 bioactivity 💉⚙️ (2019)
  • Stilbenoid prenyltransferases define key steps in the diversification of peanut phytoalexins 🌰🔬 (2018)
  • Physicochemical Properties and ACE-I Inhibitory Activity of Protein Hydrolysates from a Non-Genetically Modified Soy Cultivar 🌱⚡ (2016)